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Schizophr Res. 2014 Apr;154(1-3):30-5. doi: 10.1016/j.schres.2014.02.007. Epub 2014 Mar 1.

Valproate reverts zinc and potassium imbalance in schizophrenia-derived reprogrammed cells.

Author information

1
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Avenida Carlos Chagas, 373, bloco K, 2 andar, sala 27, Rio de Janeiro 21941, Brazil; D'Or Institute for Research Education (IDOR), Rua Diniz Cordeiro, 30, Rio de Janeiro 22281, Brazil. Electronic address: bruna.paulsen@lance-ufrj.org.
2
Institute of Physics, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos, 149 Centro de Tecnologia, bloco A, Rio de Janeiro 21941, Brazil. Electronic address: simone@if.ufrj.br.
3
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Avenida Carlos Chagas, 373, bloco K, 2 andar, sala 27, Rio de Janeiro 21941, Brazil. Electronic address: marianastelling@gmail.com.
4
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Avenida Carlos Chagas, 373, bloco K, 2 andar, sala 27, Rio de Janeiro 21941, Brazil; D'Or Institute for Research Education (IDOR), Rua Diniz Cordeiro, 30, Rio de Janeiro 22281, Brazil. Electronic address: danielcadilhe@lance-ufrj.org.
5
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Avenida Carlos Chagas, 373, bloco K, 2 andar, sala 27, Rio de Janeiro 21941, Brazil; D'Or Institute for Research Education (IDOR), Rua Diniz Cordeiro, 30, Rio de Janeiro 22281, Brazil. Electronic address: srehen@lance-ufrj.org.

Abstract

Schizophrenia has been considered a devastating clinical syndrome rather than a single disease. Nevertheless, the mechanisms behind the onset of schizophrenia have been only partially elucidated. Several studies propose that levels of trace elements are abnormal in schizophrenia; however, conflicting data generated from different biological sources prevent conclusions being drawn. In this work, we used synchrotron radiation X-ray microfluorescence spectroscopy to compare trace element levels in neural progenitor cells (NPCs) derived from two clones of induced pluripotent stem cell lines of a clozapine-resistant schizophrenic patient and two controls. Our data reveal the presence of elevated levels of potassium and zinc in schizophrenic NPCs. Neural cells treated with valproate, an adjunctive medication for schizophrenia, brought potassium and zinc content back to control levels. These results expand the understanding of atomic element imbalance related to schizophrenia and may provide novel insights for the screening of drugs to treat mental disorders.

KEYWORDS:

Induced pluripotent stem cells; Neural cells; Potassium; Schizophrenia; X-ray microfluorescence; Zinc

PMID:
24593932
DOI:
10.1016/j.schres.2014.02.007
[Indexed for MEDLINE]
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