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J Nat Prod. 2014 Apr 25;77(4):1065-8. doi: 10.1021/np400687y. Epub 2014 Mar 4.

Antiangiogenic activity of hypoxylonol C.

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Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1 Kiyose-shi, Tokyo 204-8588, Japan.


Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).

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