Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Infect Dis. 2014 Mar 4;14:127. doi: 10.1186/1471-2334-14-127.

Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women.

Author information

1
Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. susan.huntington.09@ucl.ac.uk.

Abstract

BACKGROUND:

Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started.

METHODS:

Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression.

RESULTS:

In adjusted analyses, ART-naïve (n = 1937) and ZDVm-experienced (n = 91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS.

CONCLUSIONS:

In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman's health.

PMID:
24593018
PMCID:
PMC3995971
DOI:
10.1186/1471-2334-14-127
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center