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J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14.

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Author information

1
Department of Biological Sciences, Columbia University , 550 West 120th Street Northwest Corner Building, MC 4846 New York, New York 10027, United States.

Abstract

Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.

PMID:
24592866
PMCID:
PMC3985476
DOI:
10.1021/ja411006a
[Indexed for MEDLINE]
Free PMC Article

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