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J Matern Fetal Neonatal Med. 2015 Jan;28(1):63-7. doi: 10.3109/14767058.2014.900752. Epub 2014 Apr 9.

Index pregnancy versus post-index pregnancy in patients with recurrent pregnancy loss.

Author information

1
Department of Obstetrics and Gynecology and.

Abstract

OBJECTIVE:

To compare pregnancy outcomes of two consecutive pregnancies in a cohort of women with recurrent pregnancy loss (RPL), in order to determine the long-term prognosis of women with RPL managed in a dedicated RPL clinic.

METHODS:

A retrospective cohort study including 262 patients with two or more consecutive pregnancy losses followed by two subsequent pregnancies--index pregnancy (IP) and post-index pregnancy (PIP). All patients were evaluated and treated in the RPL clinic in the Soroka University Medical Center.

RESULTS:

Comparing IP with PIP, no significant difference in perinatal outcome was observed. The perinatal outcome remained encouraging with approximately 73% birth rate (73.7% versus 72.5%; p=0.83). Only 11% of the women with RPL continued to experience pregnancy losses for two subsequent pregnancies. In a multivariate logistic regression analysis, number of miscarriages pre-Index was the only factor independently associated with birth in the PIP.

CONCLUSION:

There is no significant difference between IP and PIP regarding perinatal outcome. Appropriate management in the RPL clinic conferred a significant beneficial effect on long-term pregnancy outcome of a cohort of women with RPL.

KEYWORDS:

Birth rate; index pregnancy; long-term outcome; post-index pregnancy; pregnancy outcome; recurrent miscarriage; recurrent pregnancy loss

PMID:
24592815
DOI:
10.3109/14767058.2014.900752
[Indexed for MEDLINE]

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