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Biomed Res Int. 2014;2014:458592. doi: 10.1155/2014/458592. Epub 2014 Jan 29.

Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects.

Author information

1
Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
2
Department of Pulmonary Medicine, Wilhelminenspital Vienna, 1160 Vienna, Austria.
3
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, 1090 Vienna, Austria.

Abstract

PURPOSE:

Heme oxygenase-1 (HO-1) has been proposed to exert pharmacological benefits by its antioxidative and anti-inflammatory effects. HO-1 expression may be affected by the GT length polymorphism in the promoter region of the HO-1 gene. We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism.

METHODS:

In an open label uncontrolled phase-1 pilot study, ten male subjects received 12 g of oral curcumin. To investigate the effects of the GT length polymorphism on the inducibility of HO-1, five subjects with homozygous short and five with homozygous long GT genotypes were studied. Plasma concentrations of curcumin, bilirubin, HO-1 mRNA, and protein expression in peripheral blood mononuclear cells (PBMCs) were analyzed over 48 hours.

RESULTS:

At a detection limit of 1 µg/mL curcumin could not be detected in plasma of any subject. Compared to baseline, HO-1 mRNA and protein levels were not induced in PBMCs at any time point up to 48 hours. There was no correlation between any of the parameters and GT length polymorphism.

CONCLUSIONS:

Oral curcumin administration has low bioavailability and does not induce HO-1 on mRNA or protein level in PBMCs.

PMID:
24592391
PMCID:
PMC3925623
DOI:
10.1155/2014/458592
[Indexed for MEDLINE]
Free PMC Article

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