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Case Rep Nephrol. 2014;2014:159370. doi: 10.1155/2014/159370. Epub 2014 Jan 30.

Membranoproliferative glomerulonephritis in patients with chronic venous catheters: a case report and literature review.

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Division of Nephrology and Hypertension, Department of Internal Medicine, UCLA-Olive View Medical Center, 14445 Olive View Drive, 2B-182, Sylmar, CA 91342, USA.
Cedars Sinai Medical Center, Department of Pathology, Los Angeles, CA 90048, USA.
David Geffen School of Medicine at UCLA, Kidney and Pancreas Transplant Program, Los Angeles, CA 90095, USA.


Chronic indwelling catheters have been reported to be associated with membranoproliferative glomerulonephritis (MPGN) via the activation of the classical complement pathway in association with bacterial infections such as coagulase negative staphylococcus. We herein provide supporting evidence for the direct causal relationship between chronic catheter infections and MPGN via a case of recurrent MPGN associated with recurrent catheter infections used for total parenteral nutrition (TPN) in a man with short gut syndrome. We also present a literature review of similar cases and identify common clinical manifestations that may serve to aid clinicians in the early identification of MPGN associated with infected central venous catheterization or vice versa. The importance of routine monitoring of kidney function and urinalysis among patients with chronic central venous catheterization is highlighted as kidney injury may herald or coincide with overtly infected chronic indwelling central venous catheters.

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