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Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5135-40. doi: 10.1073/pnas.1400975111. Epub 2014 Mar 3.

Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization.

Author information

1
Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Ministry of Agriculture, Maize Research Institute of Sichuan Agricultural University, Wenjiang 611130, China.

Abstract

As an economic crop, pepper satisfies people's spicy taste and has medicinal uses worldwide. To gain a better understanding of Capsicum evolution, domestication, and specialization, we present here the genome sequence of the cultivated pepper Zunla-1 (C. annuum L.) and its wild progenitor Chiltepin (C. annuum var. glabriusculum). We estimate that the pepper genome expanded ∼0.3 Mya (with respect to the genome of other Solanaceae) by a rapid amplification of retrotransposons elements, resulting in a genome comprised of ∼81% repetitive sequences. Approximately 79% of 3.48-Gb scaffolds containing 34,476 protein-coding genes were anchored to chromosomes by a high-density genetic map. Comparison of cultivated and wild pepper genomes with 20 resequencing accessions revealed molecular footprints of artificial selection, providing us with a list of candidate domestication genes. We also found that dosage compensation effect of tandem duplication genes probably contributed to the pungent diversification in pepper. The Capsicum reference genome provides crucial information for the study of not only the evolution of the pepper genome but also, the Solanaceae family, and it will facilitate the establishment of more effective pepper breeding programs.

KEYWORDS:

Solanaceae evolution; de novo genome sequence; genome expansion

Comment in

PMID:
24591624
PMCID:
PMC3986200
DOI:
10.1073/pnas.1400975111
[Indexed for MEDLINE]
Free PMC Article
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