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Nutrients. 2014 Feb 28;6(3):931-49. doi: 10.3390/nu6030931.

The effect of multivitamin/mineral supplements on age-related cataracts: a systematic review and meta-analysis.

Author information

1
Department of Ophthalmology, No. 181 Hospital of the PLA, No.1 Xinqiaoyuan Road, Guilin 541002, China. zlq20121113@outlook.com.
2
Department of Ophthalmology, No. 181 Hospital of the PLA, No.1 Xinqiaoyuan Road, Guilin 541002, China. llm3891288@163.com.
3
Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. zhuwjp@sh163.net.
4
Department of Ophthalmology, No. 181 Hospital of the PLA, No.1 Xinqiaoyuan Road, Guilin 541002, China.

Abstract

Antioxidant vitamins supplements have been suggested as a strategy to decrease the risk of age-related cataract development. However, the results from observational studies and interventional trials of associations between antioxidant vitamins A, C, and E and cataract development have been inconsistent. We aim to evaluate the effectiveness of multivitamin/mineral supplements for decreasing the risk of age-related cataracts by conducting a systematic review and meta-analysis. In September 2013, we searched multiple databases to identify relevant studies including both cohort studies and randomized controlled trials (RCTs). A random-effects model was used to calculate the pooled relative risks (RR) with a 95% confidence interval (CI). Twelve prospective cohort studies and two RCTs were included. Pooled results from the cohort studies indicated that multivitamin/mineral supplements have a significant beneficial effect in decreasing the risk of nuclear cataracts (RR: 0.73; 95% CI: 0.64-0.82), cortical cataracts (RR: 0.81; 95% CI: 0.68-0.94), and any cataracts (RR: 0.66; 95% CI: 0.39-0.93). In addition, there were no decreases in the risk of posterior capsular cataracts (RR: 0.96; 95% CI: 0.72-1.20) or cataract surgery (RR: 1.00; 95% CI: 0.92-1.08). The two RCTs demonstrated that multivitamin/mineral supplements could decrease the risk of nuclear cataracts. There is sufficient evidence to support the role of dietary multivitamin/mineral supplements for the decreasing the risk of age-related cataracts.

PMID:
24590236
PMCID:
PMC3967170
DOI:
10.3390/nu6030931
[Indexed for MEDLINE]
Free PMC Article

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