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Biochim Biophys Acta. 2014 Apr;1845(2):294-307. doi: 10.1016/j.bbcan.2014.02.004. Epub 2014 Feb 28.

Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Author information

1
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
2
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Boston Children's Hospital, Boston, MA, USA.
3
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
4
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
5
Departement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France.
6
Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: mark_kieran@dfci.harvard.edu.

Abstract

Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.

KEYWORDS:

BRAF; Genetics; Low-grade glioma; Pediatric

PMID:
24589977
PMCID:
PMC4082403
DOI:
10.1016/j.bbcan.2014.02.004
[Indexed for MEDLINE]
Free PMC Article

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