Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2014 Apr;35(4):159-69. doi: 10.1016/j.it.2014.01.003. Epub 2014 Mar 1.

Cellular immune controls over Epstein-Barr virus infection: new lessons from the clinic and the laboratory.

Author information

1
School of Cancer Sciences and Centre for Human Virology, University of Birmingham, Birmingham, UK. Electronic address: A.B.Rickinson@bham.ac.uk.
2
School of Cancer Sciences and Centre for Human Virology, University of Birmingham, Birmingham, UK.
3
Centenary Institute, University of Sydney, Sydney, Australia.
4
Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.

Abstract

Epstein-Barr virus (EBV), a human herpesvirus with potent B cell growth transforming ability, induces multiple cellular immune responses in the infected host. How these host responses work together to prevent virus pathogenicity, and how immune imbalance predisposes to disease, remain poorly understood. Here, we describe three ongoing lines of enquiry that are shedding new light on these issues. These focus on: (i) patients with infectious mononucleosis or its fatal equivalent, X-linked lymphoproliferative disease; (ii) EBV infection in a range of new, genetically defined, primary immune deficiency states; and (iii) experimental infection in two complementary animal models, the rhesus macaque and the human haemopoietic stem cell reconstituted mouse.

KEYWORDS:

Epstein–Barr virus; NK cells; T cells; animal models; immunodeficiency

PMID:
24589417
DOI:
10.1016/j.it.2014.01.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center