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Hematol Oncol Clin North Am. 2014 Apr;28(2):341-54. doi: 10.1016/j.hoc.2013.11.010. Epub 2014 Jan 17.

Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.

Author information

1
Division of Hematology, Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Box 2615, Durham, NC 27710, USA. Electronic address: marilyn.telen@duke.edu.

Abstract

The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.

KEYWORDS:

Adhesion; Endothelium; Integrins; Selectins; Sickle cell disease

PMID:
24589270
DOI:
10.1016/j.hoc.2013.11.010
[Indexed for MEDLINE]
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