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Hematol Oncol Clin North Am. 2014 Apr;28(2):265-86. doi: 10.1016/j.hoc.2013.11.006. Epub 2014 Jan 18.

Inflammatory mediators of endothelial injury in sickle cell disease.

Author information

1
Department of Hematology-Oncology, Children's Hospital & Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA. Electronic address: choppe@mail.cho.org.

Abstract

Inflammation plays a critical role in the complex pathophysiology of sickle cell disease and drives both the acute and chronic processes leading to vascular injury. Mediators of inflammation, such as cellular adhesion molecules, cytokines, leukotrienes, and nuclear factor κB signaling factors, represent potential therapeutic targets in sickle cell disease.

KEYWORDS:

Inflammation; Mediators; Sickle cell

PMID:
24589266
DOI:
10.1016/j.hoc.2013.11.006
[Indexed for MEDLINE]

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