Send to

Choose Destination
Hepatol Int. 2013 Aug 30;7 Suppl 2:771-81. doi: 10.1007/s12072-013-9468-6. eCollection 2013 Dec.

Immune and inflammatory pathways in NASH.

Author information

Department of Medicine, University of Massachusetts Medical School, LRB208, 364 Plantation Street, Worcester, MA 01605 USA.


Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.


DAMPs; Immunity; Inflammation; NAFLD; NASH; PAMPs

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center