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Hepatol Int. 2013 Aug 30;7 Suppl 2:771-81. doi: 10.1007/s12072-013-9468-6. eCollection 2013 Dec.

Immune and inflammatory pathways in NASH.

Author information

1
Department of Medicine, University of Massachusetts Medical School, LRB208, 364 Plantation Street, Worcester, MA 01605 USA.

Abstract

Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.

KEYWORDS:

DAMPs; Immunity; Inflammation; NAFLD; NASH; PAMPs

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