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Interdiscip Perspect Infect Dis. 2014;2014:715279. doi: 10.1155/2014/715279. Epub 2014 Jan 22.

Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women: In the Context of CD38 and HLA-DR Activation Markers.

Author information

1
Kisii University, P.O. Box 408-40200, Kisii, Kenya.
2
Department of Immunology, Moi University, P.O. Box 4606-30100, Eldoret, Kenya.
3
Department of Reproductive Health, Moi University, P.O. Box 4606-30100, Eldoret, Kenya.

Abstract

BACKGROUND:

To date the effect of pregnancy on the immune activation of CD8 T cells that may affect HIV disease progression has not been well studied and remains unclear.

OBJECTIVE:

To determine the effect of pregnancy on CD8 T lymphocyte activation and its relationship with CD4 count in HIV infected pregnant women.

STUDY DESIGN:

Case control.

STUDY SITE:

AMPATH and MTRH in Eldoret, Kenya.

STUDY SUBJECTS:

Newly diagnosed asymptomatic HIV positive pregnant and nonpregnant women with no prior receipt of antiretroviral medications.

STUDY METHODS:

Blood samples were collected from the study participants and levels of activated CD8 T lymphocytes (CD38 and HLA-DR) were determined using flow cytometer and correlated with CD4 counts of the study participants. The descriptive data focusing on frequencies, correlation, and cross-tabulations was statistically determined. Significance of the results was set at P < 0.05.

RESULTS:

HIV positive pregnant women had lower activated CD8 T lymphocyte counts than nonpregnant HIV positive women. Activated CD8 T lymphocyte counts were also noted to decrease in the second and third trimesters of pregnancy.

CONCLUSION:

Pregnancy has a significant suppression on CD8+ T lymphocyte immune activation during HIV infections. Follow-up studies with more control arms could confirm the present study results.

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