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J Cell Sci. 2014 Mar 1;127(Pt 5):923-8. doi: 10.1242/jcs.093773.

Classes of phosphoinositide 3-kinases at a glance.

Author information

1
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0380, USA.

Abstract

The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes in the cell to regulate a wide range of signaling, membrane trafficking and metabolic processes. There is a broadening recognition of the importance of distinct roles for each of the three different PI3K classes (I, II and III), as well as for the different isoforms within each class. Ongoing issues include the need for a better understanding of the in vivo complexity of PI3K regulation and cellular functions. This Cell Science at a Glance article and the accompanying poster summarize the biochemical activities, cellular roles and functional requirements for the three classes of PI3Ks. In doing so, we aim to provide an overview of the parallels, the key differences and crucial interplays between the regulation and roles of the three PI3K classes.

KEYWORDS:

Class I PI3K; Class II PI3K; Class III PI3K; PI3-kinases; PI3K; Phosphoinositide

PMID:
24587488
PMCID:
PMC3937771
DOI:
10.1242/jcs.093773
[Indexed for MEDLINE]
Free PMC Article

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