NOD2 polymorphisms associated with cancer risk: a meta-analysis

Jingwei Liu; Caiyun He; Qian Xu; Chengzhong Xing; Yuan Yuan

doi:10.1371/journal.pone.0089340

NOD2 polymorphisms associated with cancer risk: a meta-analysis

PLoS One. 2014 Feb 20;9(2):e89340. doi: 10.1371/journal.pone.0089340. eCollection 2014.

Authors

Jingwei Liu¹, Caiyun He¹, Qian Xu¹, Chengzhong Xing¹, Yuan Yuan¹

Affiliation

¹ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China ; Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang, China.

Abstract

Background: Emerging evidence indicated that common polymorphisms of NOD2 might impact individual susceptibility to cancer. However, the results from published studies were inconclusive. The aim of this meta-analysis was to elucidate whether NOD2 polymorphisms were associated with cancer risk.

Methods: A systematically literature search was performed by using electronic databases including PubMed and Web of Science. ORs and their 95% CI were used to assess the strength of association between NOD2 gene polymorphisms and cancer risks.

Results: Thirty case-control studies were included in this meta-analysis. The pooled analysis indicated that NOD2 rs2066842 C/T polymorphism was not significantly associated with cancer risk; for NOD2 rs2066844 C/T polymorphism, (TT+CT) genotype was associated with increased cancer risk compared with wild-type CC genotype (OR = 1.32, 95% CI = 1.01-1.72, P = 0.041); for NOD2 rs2066845 C/G polymorphism, individuals with (CC+CG) genotype were significantly associated with increased cancer risk compared with GG genotype (OR = 1.32, 95% CI = 1.01-1.72, P = 0.040); for NOD2 rs2066847 (3020insC) polymorphism, carriers of (insC/insC+insC/-) genotype were significantly associated with increased cancer risk compared with -/- carriers (OR = 1.23, 95% CI = 1.10-1.38, P<0.001). In the subgroup analysis of cancer type, (insC/insC+insC/-) genotype was significantly associated with increased risk of colorectal cancer, gastric cancer and MALT lymphoma, breast cancer, lung cancer, laryngeal cancer but not with urogenital cancer, pancreatic cancer, melanoma or non-Hodgkin lymphoma.

Conclusion: NOD2 rs2066844 C/T, rs2066845 C/G and rs2066847 (3020insC) polymorphisms might be associated with increased cancer risk. No significant association was observed between NOD2 rs2066842 C/T polymorphism and cancer risk. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Genetic Predisposition to Disease*
Humans
Neoplasms / genetics*
Neoplasms / pathology
Nod2 Signaling Adaptor Protein / genetics*
Polymorphism, Genetic / genetics*
Prognosis
Risk Assessment

Substances

NOD2 protein, human
Nod2 Signaling Adaptor Protein

Grants and funding

This study is supported by grants from National Basic Research Program of China (973 Program Ref No.2010CB529304), the grants of the Science and Technology Project of Liaoning province (Ref No.2011225002) and the grants of the Science and Technology Project of Liaoning province (Ref No.2012225016). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.