Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2014 Feb 21;9(2):e88956. doi: 10.1371/journal.pone.0088956. eCollection 2014.

Diabetic nephropathy and its risk factors in a society with a type 2 diabetes epidemic: a Saudi National Diabetes Registry-based study.

Author information

1
University Diabetes Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
2
Registry Department, University Diabetes Center, King Saud University, Riyadh, Saudi Arabia.
3
Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
4
Biostatistics Department, University Diabetes Center, King Saud University, Riyadh, Saudi Arabia.
5
Family and Community Medicine Department, Qassim University, Qassim, Saudi Arabia.
6
Information Technology Department, Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia.
7
Research Department, University Diabetes Center, King Saud University, Riyadh Saudi Arabia.

Abstract

AIMS:

The prevalence of diabetic nephropathy and its risk factors have not been studied in a society known to have diabetes epidemic like Saudi Arabia. Using a large data base registry will provide a better understanding and accurate assessment of this chronic complication and its related risk factors.

METHODOLOGY:

A total of 54,670 patients with type 2 diabetes aged ≥ 25 years were selected from the Saudi National Diabetes Registry (SNDR) and analyzed for the presence of diabetic nephropathy. The American Diabetes Association (ADA) criterion was used to identify cases with microalbuminuria, macroalbuminuria and end stage renal disease (ESRD) for prevalence estimation and risk factor assessment.

RESULTS:

The overall prevalence of diabetic nephropathy was 10.8%, divided into 1.2% microalbuminuria, 8.1%macroalbuninuria and 1.5% ESRD. Age and diabetes duration as important risk factors have a strong impact on the prevalence of diabetic nephropathy, ranging from 3.7% in patients aged 25-44 years and a duration of >5 years, to 21.8% in patients ≥ 65 years with a diabetes duration of ≥ 15 years. Diabetes duration, retinopathy, neuropathy, hypertension, age >45 years, hyperlipidemia, male gender, smoking, and chronologically, poor glycemic control has a significantly high risk for diabetic nephropathy.

CONCLUSION:

The prevalence of diabetic nephropathy is underestimated as a result of a shortage of screening programs. Risk factors related to diabetic nephropathy in this society are similar to other societies. There is thus an urgent need for screening and prevention programs for diabetic nephropathy among the Saudi population.

PMID:
24586457
PMCID:
PMC3931705
DOI:
10.1371/journal.pone.0088956
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center