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PLoS Pathog. 2014 Feb 20;10(2):e1003905. doi: 10.1371/journal.ppat.1003905. eCollection 2014 Feb.

Tailored immune responses: novel effector helper T cell subsets in protective immunity.

Author information

1
School of Molecular & Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia.

Abstract

Differentiation of naïve CD4⁺ cells into functionally distinct effector helper T cell subsets, characterised by distinct "cytokine signatures," is a cardinal strategy employed by the mammalian immune system to efficiently deal with the rapidly evolving array of pathogenic microorganisms encountered by the host. Since the T(H)1/T(H)2 paradigm was first described by Mosmann and Coffman, research in the field of helper T cell biology has grown exponentially with seven functionally unique subsets having now been described. In this review, recent insights into the molecular mechanisms that govern differentiation and function of effector helper T cell subsets will be discussed in the context of microbial infections, with a focus on how these different helper T cell subsets orchestrate immune responses tailored to combat the nature of the pathogenic threat encountered.

PMID:
24586147
PMCID:
PMC3930558
DOI:
10.1371/journal.ppat.1003905
[Indexed for MEDLINE]
Free PMC Article

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