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PLoS Comput Biol. 2014 Feb 27;10(2):e1003493. doi: 10.1371/journal.pcbi.1003493. eCollection 2014 Feb.

A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.

Author information

1
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
2
University of Washington, Seattle, Washington, United States of America ; Swedish Medical Center, Seattle, Washington, United States of America.
3
Jahangirnagar University, Savar, Dhaka, Bangladesh.
4
University of Washington, Seattle, Washington, United States of America.

Abstract

Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.

PMID:
24586139
PMCID:
PMC3937129
DOI:
10.1371/journal.pcbi.1003493
[Indexed for MEDLINE]
Free PMC Article
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