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Asian Cardiovasc Thorac Ann. 2014 Feb;22(2):203-4. doi: 10.1177/0218492312467993. Epub 2013 Jul 11.

HeartWare left ventricular assist device thrombosis in aspirin non-responder.

Author information

1
Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Patient characteristics that increase the risk of continuous-flow left ventricular assist device thrombosis have not been well established. We report a case of HeartWare thrombosis in a patient with aspirin hyporesponsiveness, and discuss the role of platelet function testing in preventing this severe complication. There is a need for clinical trials determining optimal antiplatelet therapy in patients supported with left ventricular assist devices, and consensus regarding modification of antiplatelet therapy after device thrombosis.

KEYWORDS:

Aspirin; drug resistance; heart-assist devices; platelet aggregation; thromboembolism

PMID:
24585795
DOI:
10.1177/0218492312467993
[Indexed for MEDLINE]

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