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Genesis. 2014 Jun;52(6):471-80. doi: 10.1002/dvg.22763. Epub 2014 Mar 17.

The myosin ID pathway and left-right asymmetry in Drosophila.

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Université de Nice Sophia Antipolis, institut de Biologie Valrose, iBV, Parc Valrose, Nice cedex 2, France; CNRS, institut de Biologie Valrose, iBV, UMR 7277, Parc Valrose, Nice cedex 2, France; INSERM, institut de Biologie Valrose, iBV, U1091, Parc Valrose, Nice cedex 2, France.


Drosophila is a classical model to study body patterning, however left-right (L/R) asymmetry had remained unexplored, until recently. The discovery of the conserved myosin ID gene as a major determinant of L/R asymmetry has revealed a novel L/R pathway involving the actin cytoskeleton and the adherens junction. In this process, the HOX gene Abdominal-B plays a major role through the control of myosin ID expression and therefore symmetry breaking. In this review, we present organs and markers showing L/R asymmetry in Drosophila and discuss our current understanding of the underlying molecular genetic mechanisms. Drosophila represents a valuable model system revealing novel strategies to establish L/R asymmetry in invertebrates and providing an evolutionary perspective to the problem of laterality in bilateria.


HOX gene Abdominal-B; asymmetric morphogenesis in invertebrates; developmental biology; diptera; genetic; invertebrates; left-right asymmetry; morphogenesis; symmetry breaking; unconventional type I myosin

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