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Curr Opin Genet Dev. 2014 Apr;25:1-7. doi: 10.1016/j.gde.2013.10.014. Epub 2013 Dec 12.

Manipulating nuclear architecture.

Author information

1
Transcription Imaging Consortium, Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, United States.
2
Division of Hematology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: blobel@email.chop.edu.

Abstract

The eukaryotic genome is highly organized in the nucleus. Genes can be localized to specific nuclear compartments in a manner reflecting their activity. A plethora of recent reports has described multiple levels of chromosomal folding that can be related to gene-specific expression states. Here we discuss studies designed to probe the causal impact of genome organization on gene expression. The picture that emerges is that of a reciprocal relationship in which nuclear organization is not only shaped by gene expression states but also directly influences them.

PMID:
24584091
PMCID:
PMC4035372
DOI:
10.1016/j.gde.2013.10.014
[Indexed for MEDLINE]
Free PMC Article

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