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Physiology (Bethesda). 2014 Mar;29(2):99-107. doi: 10.1152/physiol.00050.2013.

AMPK: regulating energy balance at the cellular and whole body levels.

Author information

1
Division of Cell Signalling & Immunology, College of Life Sciences, and Division of Cardiovascular and Diabetes Medicine, College of Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland, United Kingdom.

Abstract

AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.

PMID:
24583766
PMCID:
PMC3949207
DOI:
10.1152/physiol.00050.2013
[Indexed for MEDLINE]
Free PMC Article

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