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Genetics. 2014 May;197(1):401-4. doi: 10.1534/genetics.113.158014. Epub 2014 Feb 28.

Efficient imputation of missing markers in low-coverage genotyping-by-sequencing data from multiparental crosses.

Author information

1
Computational Informatics and Food Futures Flagship, Commonwealth Scientific and Industrial Research Organization, Dutton Park, Queensland, Australia 4102.

Abstract

We consider genomic imputation for low-coverage genotyping-by-sequencing data with high levels of missing data. We compensate for this loss of information by utilizing family relationships in multiparental experimental crosses. This nearly quadruples the number of usable markers when applied to a large rice Multiparent Advanced Generation InterCross (MAGIC) study.

KEYWORDS:

GBS; HMM; MAGIC; MPRIL

PMID:
24583583
PMCID:
PMC4012496
DOI:
10.1534/genetics.113.158014
[Indexed for MEDLINE]
Free PMC Article
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