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Clin Neurophysiol. 2014 Sep;125(9):1809-18. doi: 10.1016/j.clinph.2014.01.010. Epub 2014 Jan 29.

Within-session repeated a-tDCS: the effects of repetition rate and inter-stimulus interval on corticospinal excitability and motor performance.

Author information

1
Department of Physiotherapy, School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia. Electronic address: andisheh.bastanijahromi@monash.edu.
2
Department of Physiotherapy, School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Abstract

OBJECTIVE:

This study investigated the effect of rate and stimulation interval of anodal transcranial direct current stimulation (a-tDCS) on CSE and motor performance.

METHODS:

Twelve healthy individuals participated in this study. CSE was assessed before and after five experimental conditions of one, two or three applications of 10 min of a-tDCS with an interval of 5 or 25 min. a-tDCS was applied with a constant current density of 0.016 mA/cm(2). Purdue pegboard-test was selected for motor performance assessment.

RESULTS:

Compared to single 10 min stimulation, the magnitude of the within-session repeated a-tDCS induced excitability was enhanced significantly after the second stimulation was performed with an interval of 25 min, but not 5 min. However, by increasing the number of a-tDCS to three repetitions the CSE was significantly increased and lasted for 2h with both 5 and 25 min intervals. Furthermore, CSE enhancement remained significant for up to 24h for within session a-tDCS repetitions with 25 min intervals. Likewise, significant improvement was seen in motor performance following three times repetition with 25 min inter-stimulus intervals.

CONCLUSIONS:

The results suggest that within session repeated a-tDCS with longer intervals within the lasting effects of the previous stimulations are preferable for increasing induced excitability changes with longer lasting effects.

SIGNIFICANCE:

It is of particular importance to increase the a-tDCS lasting effects to consolidate the neuroplastic CSE changes.

KEYWORDS:

Non-invasive brain stimulation; Optimal tDCS parameter; Plasticity; Transcranial direct current stimulation; Transcranial magnetic stimulation

PMID:
24582469
DOI:
10.1016/j.clinph.2014.01.010
[Indexed for MEDLINE]

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