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Endocrinol Metab Clin North Am. 2014 Mar;43(1):205-32. doi: 10.1016/j.ecl.2013.09.010. Epub 2013 Dec 12.

Vitamin D and diabetes.

Author information

1
Division of Endocrinology, Diabetes and Metabolism, Prima CARE Medical Center, 277 Pleasant Street, Fall River, MA 02721, USA. Electronic address: joannamitri@hotmail.com.
2
Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

Abstract

There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.

KEYWORDS:

25-hydroxyvitamin D; Insulin resistance; Insulin sensitivity; Type 2 diabetes; Vitamin D

PMID:
24582099
PMCID:
PMC3942667
DOI:
10.1016/j.ecl.2013.09.010
[Indexed for MEDLINE]
Free PMC Article

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