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J Neuroimmunol. 2014 Apr 15;269(1-2):90-3. doi: 10.1016/j.jneuroim.2014.02.005. Epub 2014 Feb 13.

Activated microglia do not form functional gap junctions in vivo.

Author information

1
Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address: swasseff@mail.med.upenn.edu.
2
Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address: sscherer@mail.med.upenn.edu.

Abstract

We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity to glia and neurons, they do not form functional gap junctions under these pathological conditions.

KEYWORDS:

Alzheimer's disease; Astrocytes; Brain injury; Gap junctions; Microglia; Oligodendrocytes

PMID:
24582000
PMCID:
PMC4048983
DOI:
10.1016/j.jneuroim.2014.02.005
[Indexed for MEDLINE]
Free PMC Article
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