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Arch Oral Biol. 2014 Mar;59(3):258-67. doi: 10.1016/j.archoralbio.2013.12.001. Epub 2013 Dec 8.

Long-term curcumin treatment antagonizes masseter muscle alterations induced by chronic unpredictable mild stress in rats.

Author information

1
Department of General Dentistry & Emergency, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
2
Department of General Dentistry & Emergency, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. Electronic address: zhangmin@fmmu.edu.cn.
3
Department of General Dentistry & Emergency, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China. Electronic address: cyj1229@fmmu.edu.cn.

Abstract

OBJECTIVE:

To investigate the correlation between psychological stress and masseter muscle (MM) alterations, and explore the therapeutic agents for restoring the impaired masticatory muscle.

DESIGN:

We established a chronic unpredictable mild stress (CUMS) animal model and observed the changes of ultrastructure, redox homeostasis and energy metabolism in MM in rats with and without curcumin treatment.

RESULTS:

The depressive-like behavior in stressed rats was confirmed by the evidences of altered behaviors in sucrose preference test and open field test; while these phenomena were eased by curcumin. Except for the pathological changes in ultrastructure, decreased SOD, GSH-Px, CAT, Na(+)-K(+)ATPase, and Ca(2+)-Mg(2+)ATPase activities as well as increased MDA and LD content and LDH activity were also observed in MM in stressed rats. However, curcumin was capable of reversing CUMS-induced MM disorder by improving the activities of the examined anti-oxidant enzymes and energy metabolism enzymes. Additionally, the increased MDA content, LD content, and LDH activity in stressed rats were reduced by curcumin.

CONCLUSION:

All the findings indicate the adverse effects of CUMS on MM function in rats, and raise the possibility of developing curcumin as a potential therapeutic agent for psychological stress-induced masseter dysfunction.

KEYWORDS:

CUMS; Curcumin; Masseter muscle; Metabolic disorder; Oxidative stress

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