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Curr Opin Microbiol. 2014 Feb;17:82-90. doi: 10.1016/j.mib.2013.12.001. Epub 2013 Dec 29.

Impact of CRISPR immunity on the emergence and virulence of bacterial pathogens.

Author information

1
Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
2
Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: marraffini@rockefeller.edu.

Abstract

CRISPR-Cas systems protect prokaryotes from viruses and plasmids and function primarily as an adaptive immune system in these organisms. Recent discoveries, however, revealed unexpected roles for CRISPR loci as barriers to horizontal gene transfer and as modulators of gene expression. We review how both of these functions of CRISPR-Cas systems can affect the emergence and virulence of human bacterial pathogens.

PMID:
24581697
PMCID:
PMC3942673
DOI:
10.1016/j.mib.2013.12.001
[Indexed for MEDLINE]
Free PMC Article

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