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Fertil Steril. 2014 May;101(5):1400-3. doi: 10.1016/j.fertnstert.2014.01.036. Epub 2014 Feb 26.

A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility.

Author information

1
Department of Obstetrics and Gynecology, Stanford University Hospital, Stanford, California. Electronic address: jkort@stanford.edu.
2
Stanford University School of Medicine, Stanford, California.
3
Division of Endocrinology, Department of Medicine, Stanford University Hospital, Stanford, California.
4
Department of Reproductive Endocrinology and Infertility, Stanford University Hospital, Stanford, California.

Abstract

OBJECTIVE:

To determine if meaningful weight loss (≥10%) improved conception and live birth rates of overweight patients with infertility.

DESIGN:

A retrospective cohort study.

SETTING:

Academic medical center.

PATIENT(S):

Overweight patients (body mass index ≥25 kg/m(2); n = 52) being treated for infertility and referred for weight loss counseling.

INTERVENTION(S):

Patients were given a "meaningful" weight loss goal of 10%. They were followed by an endocrinologist who provided diet and exercise recommendations, metabolic screening, and pharmacologic intervention when indicated.

MAIN OUTCOME MEASURE(S):

Pregnancy rate, live birth rate, weight loss.

RESULT(S):

Thirty-two percent of the patients achieved meaningful weight loss. Patients achieving meaningful weight loss had significantly higher conception (88% vs. 54%) and live birth rates (71% vs. 37%) than those who did not.

CONCLUSION(S):

Weight loss improves live birth rates in overweight patients with infertility. Health care providers should incorporate weight loss counseling when caring for overweight patients who plan to conceive.

KEYWORDS:

BMI; Obesity; infertility; overweight; weight loss

[Indexed for MEDLINE]

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