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Cell. 2014 Feb 27;156(5):868-9. doi: 10.1016/j.cell.2014.02.004.

Nuclear pores set the speed limit for mitosis.

Author information

1
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA.
2
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA. Electronic address: hetzer@salk.edu.

Abstract

The spindle assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, providing a store of inhibitory signals that limits the speed of the subsequent mitosis.

PMID:
24581486
PMCID:
PMC4008093
DOI:
10.1016/j.cell.2014.02.004
[Indexed for MEDLINE]
Free PMC Article
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