Format

Send to

Choose Destination
Genome Biol. 2014 Mar 3;15(3):R47. doi: 10.1186/gb-2014-15-3-r47.

Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines.

Abstract

We demonstrate a method for the prediction of chemotherapeutic response in patients using only before-treatment baseline tumor gene expression data. First, we fitted models for whole-genome gene expression against drug sensitivity in a large panel of cell lines, using a method that allows every gene to influence the prediction. Following data homogenization and filtering, these models were applied to baseline expression levels from primary tumor biopsies, yielding an in vivo drug sensitivity prediction. We validated this approach in three independent clinical trial datasets, and obtained predictions equally good, or better than, gene signatures derived directly from clinical data.

PMID:
24580837
PMCID:
PMC4054092
DOI:
10.1186/gb-2014-15-3-r47
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center