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Annu Rev Biochem. 2014;83:99-128. doi: 10.1146/annurev-biochem-060713-035600. Epub 2014 Feb 21.

Biosynthesis and export of bacterial lipopolysaccharides.

Author information

1
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada; email: cwhitfie@uoguelph.ca.

Abstract

Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly conserved lipid moiety known as lipid A. These molecules are produced by most gram-negative bacteria, in which they play important roles in the integrity of the outer-membrane permeability barrier and participate extensively in host-pathogen interplay. Few bacteria contain lipopolysaccharide molecules composed only of lipid A. In most forms, lipid A is glycosylated by addition of the core oligosaccharide that, in some bacteria, provides an attachment site for a long-chain O-antigenic polysaccharide. The complexity of lipopolysaccharide structures is reflected in the processes used for their biosynthesis and export. Rapid growth and cell division depend on the bacterial cell's capacity to synthesize and export lipopolysaccharide efficiently and in large amounts. We review recent advances in those processes, emphasizing the reactions that are essential for viability.

KEYWORDS:

biosynthesis; endotoxin; gram-negative bacteria; lipid A; macromolecular trafficking; outer membranes

[Indexed for MEDLINE]

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