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Front Physiol. 2014 Feb 27;5:82. doi: 10.3389/fphys.2014.00082. eCollection 2014.

Gap junction modulation and its implications for heart function.

Author information

1
Department of Psychology, Faculty of Health, York University Toronto, ON, Canada.
2
Department of Psychology, Faculty of Health, York University Toronto, ON, Canada ; Department of Biology, Faculty of Science, York University Toronto, ON, Canada ; Center for Vision Research, York University Toronto, ON, Canada.

Abstract

Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.

KEYWORDS:

connexin; gap junction communication; heart; interactome; signaling pathway

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