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J Exp Biol. 2014 Jun 1;217(Pt 11):1894-901. doi: 10.1242/jeb.101725. Epub 2014 Feb 27.

Gut microbiota dictates the metabolic response of Drosophila to diet.

Author information

1
Department of Entomology, Cornell University, Ithaca, NY14853, USA chun.wong@sydney.edu.au.
2
Department of Entomology, Cornell University, Ithaca, NY14853, USA.
3
Department of Entomology, Cornell University, Ithaca, NY14853, USA Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY14853, USA.

Abstract

Animal nutrition is profoundly influenced by the gut microbiota, but knowledge of the scope and core mechanisms of the underlying animal-microbiota interactions is fragmentary. To investigate the nutritional traits shaped by the gut microbiota of Drosophila, we determined the microbiota-dependent response of multiple metabolic and performance indices to systematically varied diet composition. Diet-dependent differences between Drosophila bearing its unmanipulated microbiota (conventional flies) and experimentally deprived of its microbiota (axenic flies) revealed evidence for: microbial sparing of dietary B vitamins, especially riboflavin, on low-yeast diets; microbial promotion of protein nutrition, particularly in females; and microbiota-mediated suppression of lipid/carbohydrate storage, especially on high sugar diets. The microbiota also sets the relationship between energy storage and body mass, indicative of microbial modulation of the host signaling networks that coordinate metabolism with body size. This analysis identifies the multiple impacts of the microbiota on the metabolism of Drosophila, and demonstrates that the significance of these different interactions varies with diet composition and host sex.

KEYWORDS:

B vitamins; Drosophila; Gut microbiota; Hyperlipidemia; Protein nutrition; Symbiosis

PMID:
24577449
PMCID:
PMC4037322
DOI:
10.1242/jeb.101725
[Indexed for MEDLINE]
Free PMC Article

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