[Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus]

A Brown; D Neumayer; Z Rafieé-Tari; T Krieg; S A Eming

doi:10.1007/s00105-014-2762-y

[Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus]

Hautarzt. 2014 Jun;65(6):553-5. doi: 10.1007/s00105-014-2762-y.

[Article in German]

Authors

A Brown¹, D Neumayer, Z Rafieé-Tari, T Krieg, S A Eming

Affiliation

¹ Klinik und Poliklinik für Dermatologie und Venerologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

PMID: 24577262
DOI: 10.1007/s00105-014-2762-y

Abstract

Graft-versus-host-disease (GvHD) is despite improvement in transplantation medicine the major cause for morbidity and mortality after allogeneic stem cell transplantation. We describe a patient with chronic cutaneous GvHD who developed massive skin ulcerations after changing the immunosuppressive therapy to a mammalian target of rapamycin (mTOR)-inhibitor.

Publication types

Case Reports
English Abstract

MeSH terms

Everolimus
Graft vs Host Disease / drug therapy*
Graft vs Host Disease / etiology*
Humans
Immunosuppressive Agents / therapeutic use
Male
Middle Aged
Sirolimus / adverse effects
Sirolimus / analogs & derivatives*
Sirolimus / therapeutic use
Skin Ulcer / chemically induced*
Skin Ulcer / prevention & control
Stem Cell Transplantation / adverse effects*
Treatment Outcome

Substances

Immunosuppressive Agents
Everolimus
Sirolimus