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J Biol Chem. 2014 Apr 25;289(17):11642-9. doi: 10.1074/jbc.O114.556068. Epub 2014 Feb 27.

Hormonal signaling in the gut.

Author information

1
From the Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7.

Abstract

The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a neuronal gut-brain axis. Additionally, jejunal nutrient sensing and leptin action are demonstrated to suppress glucose production, and both are required for the rapid antidiabetic effect of duodenal jejunal bypass surgery. Strategies aimed at targeting local gut hormonal signaling pathways may prove to be efficacious therapeutic options to improve glucose control in diabetes.

KEYWORDS:

Bariatric Surgery; Diabetes; Fatty Acid; Food Intake; Glucose Metabolism; Hormones; Intestine

PMID:
24577102
PMCID:
PMC4002074
DOI:
10.1074/jbc.O114.556068
[Indexed for MEDLINE]
Free PMC Article
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