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Med Mycol. 2014 Apr;52(3):240-5. doi: 10.1093/mmy/myt019. Epub 2014 Feb 7.

Evaluation of in vivo pathogenicity of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis with different enzymatic profiles in a murine model of disseminated candidiasis.

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  • 1Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Abstract

Six isolates of the Candida parapsilosis complex with different enzymatic profiles were used to induce systemic infection in immunocompetent BALB/c mice. Fungal tissue burden was determined on days 2, 5, 10, and 15 post challenge. The highest fungal load irrespective of post-infection day was detected in the kidney, followed by the spleen, lung, and liver, with a tendency for the fungal burden to decrease by day 15 in all groups. Significant differences among the strains were not detected, suggesting that the three species of the "psilosis" group possess a similar pathogenic potential in disseminated candidiasis regardless of their enzymatic profiles.

KEYWORDS:

Candida metapsilosis; Candida orthopsilosis; Candida parapsilosis; disseminated candidiasis; fungal tissue burden; murine model

PMID:
24577011
DOI:
10.1093/mmy/myt019
[PubMed - indexed for MEDLINE]
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