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Nat Cell Biol. 2014 Mar;16(3):212-4. doi: 10.1038/ncb2924.

A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.

Author information

1
Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA.

Abstract

Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.

PMID:
24576899
PMCID:
PMC5453176
DOI:
10.1038/ncb2924
[Indexed for MEDLINE]
Free PMC Article

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