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RNA Biol. 2014;11(5):443-56. Epub 2014 Feb 10.

Small regulatory RNAs from low-GC Gram-positive bacteria.

Author information

1
Friedrich-Schiller-Universität Jena; Biologisch-Pharmazeutische Fakultät; AG Bakteriengenetik; Philosophenweg 12; Jena, Germany.
2
Mikrobiologie; TU Kaiserslautern; Paul-Ehrlich-Str. 23; D-67663 Kaiserslautern, Germany.

Abstract

Small regulatory RNAs (sRNAs) that act by base-pairing were first discovered in so-called accessory DNA elements--plasmids, phages, and transposons--where they control replication, maintenance, and transposition. Since 2001, a huge body of work has been performed to predict and identify sRNAs in a multitude of bacterial genomes. The majority of chromosome-encoded sRNAs have been investigated in E. coli and other Gram-negative bacteria. However, during the past five years an increasing number of sRNAs were found in Gram-positive bacteria. Here, we outline our current knowledge on chromosome-encoded sRNAs from low-GC Gram-positive species that act by base-pairing, i.e., an antisense mechanism. We will focus on sRNAs with known targets and defined regulatory mechanisms with special emphasis on Bacillus subtilis.

KEYWORDS:

Bacillus subtilis; Streptococcus pneumoniae; base-pairing sRNA; low GC Gram-positive bacteria; small regulatory RNA

PMID:
24576839
PMCID:
PMC4152353
DOI:
10.4161/rna.28036
[Indexed for MEDLINE]
Free PMC Article

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