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Biomed Opt Express. 2014 Jan 28;5(2):630-42. doi: 10.1364/BOE.5.000630. eCollection 2014 Feb 1.

Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes.

Author information

1
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
2
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
3
Imedos Systems UG, Am Nasstal 4, 07751 Jena, Germany.
4
Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
5
Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
6
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria.

Abstract

We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray's law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood's velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at lower diameters. Good agreement with literature data and the large range and high measurement sensitivity point to a high potential for further investigations.

KEYWORDS:

(170.0110) Imaging systems; (170.2655) Functional monitoring and imaging; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography; (280.2490) Flow diagnostics

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