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Iran J Ped Hematol Oncol. 2013;3(1):216-21. Epub 2013 Jan 22.

Crude Extract from Ziziphus Jujuba Fruits, a Weapon against Pediatric Infectious Disease.

Author information

1
Department of Biology, Payame Noor University, Po Box 19395-3697, Tehran, I. R. Iran.
2
Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran. ; Department of Pediatric Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
3
University of Applied Science and Technology of Sistan and Baluchestan, minushargh Branch, Zahedan, Iran.
4
Department of chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
5
Iranian Academic Center for Education, Culture and Research (ACECR), Mazandaran Branch, Sari, Iran.

Abstract

BACKGROUND:

Pediatric infectious disease is one of the main problems in cancerous children that treat by chemotherapy drugs. Thus, study in this regard is necessary. The aim of this study was to evaluate antimicrobial properties of ethanolic extract of Ziziphus Jujuba fruits against different infectious pathogens.

MATERIALS AND METHODS:

This study is descriptive. In vitro antimicrobial activity of extract was assessed on gram negative and gram positive bacteria as well as fungi. The antimicrobial activity was tested by Radial Diffusion Assay (RDA) and Minimal Inhibitory Concentration (MIC) methods.

RESULTS:

The results showed a wide antimicrobial activity of the extract against the microbes studied. Escherichia coli was the most susceptible to the extracts among tested microorganisms for which the MIC was 0.65±0.22 mg/ml. Amongst the bacterial strains investigated, Staphylococcus aureus was the most resistant strain with MIC of 2.26±0.68 mg/ml. The ethanolic extract also showed antimicrobial activity on the fungi studied as no growth was observed in 2.35±0.38 and 2.86±0.7 mg/ml concentration for Candida albicans and Aspergillus fumigatus, respectively. The results of qualitive and quantitative test are well indicative of the extract effective activity against the microbes mentioned.

CONCLUSION:

Confirming the potential antimicrobial activities of crude extract of Ziziphus Jujuba fruits, this study suggested that ethanolic extracts of this plant is appropriate candidate for treatment of microbial infections, especially pediatric infectious diseases.

KEYWORDS:

Fungi; Pediatrics; Ziziphus

PMID:
24575267
PMCID:
PMC3915445

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