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Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.

Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Author information

1
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.

Abstract

Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.

PMID:
24574537
PMCID:
PMC4018890
DOI:
10.1128/CVI.00003-14
[Indexed for MEDLINE]
Free PMC Article

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