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J Virol. 2014 May;88(10):5864-9. doi: 10.1128/JVI.00145-14. Epub 2014 Feb 26.

Local control of repeated-dose rectal challenges in DNA/MVA-vaccinated macaques protected against a first series of simian immunodeficiency virus challenges.

Author information

1
Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Abstract

Here, we report the results of a late boost and three additional series of simian immunodeficiency virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques who resisted a first series of rectal challenges. During 29 additional challenges delivered over 2.3 years, all animals became infected. However, 13 blips of virus in six macaques and anamnestic Env-specific rectal IgA responses in three of the six suggested that local control of infections was occurring during the serial challenge.

PMID:
24574408
PMCID:
PMC4019109
DOI:
10.1128/JVI.00145-14
[Indexed for MEDLINE]
Free PMC Article

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