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Adv Healthc Mater. 2014 Sep;3(9):1398-403. doi: 10.1002/adhm.201400039. Epub 2014 Feb 20.

Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles.

Author information

1
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.

Abstract

A new library of lipid-like nanoparticles (lipidoids) comprising disulfide bond is developed for siRNA delivery. Bioreducible lipidoids deliver siRNA with greater efficiency than nonbioreducible lipidoids with similar chemical structures. A siRNA release investigation, as well as an intracellular siRNA trafficking study, reveals that the degradation of bioreducible lipidoid in a strongly reductive intracellular environment boosts siRNA release and enhances siRNA gene knockdown efficiency.

KEYWORDS:

bioreducible lipidoid; cancer therapy; combinatorial; nanoparticles; siRNA delivery

PMID:
24574196
DOI:
10.1002/adhm.201400039
[Indexed for MEDLINE]

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