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J Int Med Res. 2014 Apr;42(2):554-65. doi: 10.1177/0300060513504163. Epub 2014 Feb 26.

The value of inflammatory parameters in the prognosis of malignant mesothelioma.

Author information

1
Department of Chest Diseases, Dicle University, Diyarbakir, Turkey.

Abstract

OBJECTIVE:

This study investigated the relationship between potential prognostic parameters that may be associated with increased inflammation and survival in patients with malignant mesothelioma (MM).

METHODS:

This retrospective study assessed potential prognostic parameters measured at the time of MM diagnosis. Data on asbestos exposure, histopathological subtype of MM and laboratory parameters were collected.

RESULTS:

In 155 patients with MM (90 male), mean survival time was 13.9 months. In univariate analysis, age ≥ 60 years and neutrophil-to-lymphocyte ratio (NLR) ≥ 3 were associated with significantly shortened median survival times. In multivariate analysis, nonepithelial subtype, red cell distribution width (RDW) ≥ 20% and NLR ≥ 3 were associated with significantly shortened median survival times. Mortality rate was increased 2.77-, 1.67- and 1.52-fold in patients with RDW ≥ 20%, NLR ≥ 3 and nonepithelial subtype, respectively. Nonepithelial subtype, white blood cell count ≥ 11 200 µl and platelet-to-lymphocyte ratio ≥ 300 at baseline were associated with a heightened NLR value.

CONCLUSIONS:

The NLR and RDW were significant predictive factors for MM prognosis.

KEYWORDS:

Malignant mesothelioma; neutrophil-to-lymphocyte ratio; prognosis; red cell distribution width

PMID:
24573972
DOI:
10.1177/0300060513504163
[Indexed for MEDLINE]

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