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Clin Rheumatol. 2014 Aug;33(8):1033-8. doi: 10.1007/s10067-014-2530-5. Epub 2014 Feb 27.

Vitamin D and systemic lupus erythematosus: state of the art.

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Division of Rheumatology, Hospital de ClĂ­nicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 645, Porto Alegre, 90035-003, Brazil.


Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This review of the literature presents an analysis of the aspects related to the immunoregulatory effects of vitamin D and its importance for SLE, as well as the recommendations for vitamin D supplementation in these patients.

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