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Methods Mol Biol. 2014;1137:1-15. doi: 10.1007/978-1-4939-0366-5_1.

Protein structure modeling with MODELLER.

Author information

1
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.

Abstract

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized at atomic resolution using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. In this chapter, we present an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of a similar protocol has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

PMID:
24573470
DOI:
10.1007/978-1-4939-0366-5_1
[Indexed for MEDLINE]

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