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J Invest Dermatol. 2014 Jun;134(6):1512-1518. doi: 10.1038/jid.2014.65. Epub 2014 Feb 27.

Melanocytes as instigators and victims of oxidative stress.

Author information

1
L'OREAL Research and Innovation, Aulnay-sous-Bois, France.
2
Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
3
Department of Dermatology, Oregon Health Sciences University, Portland, Oregon, USA.
4
Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: abdelmza@uc.edu.

Abstract

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses that are compromised in pathologic conditions. Melanoma is thought to be oxidative stress driven, and melanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermis. We review the current knowledge about melanin and the redox state of melanocytes, how paracrine factors help counteract oxidative stress, the role of oxidative stress in melanoma initiation and progression and in melanocyte death in vitiligo, and how this knowledge can be harnessed for melanoma and vitiligo treatment.

PMID:
24573173
PMCID:
PMC4418514
DOI:
10.1038/jid.2014.65
[Indexed for MEDLINE]
Free PMC Article

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